Is a loss in September worse than one in April?
One side of the argument says that they both count the same towards a team's final record. 81-81 is the same whether you started 81-0 or 0-81, even if the stories are quite different.
One side of the argument says that there's plenty of time to make up for a loss in April, whereas each loss in September is as important for how much closer it brings the season to an end as for its effect on the old record.
The last side of the argument says that the Red Sox are already AL East Champions which would seem to take quite a bit of meaning out of any loss they suffer from here-on-out, yes.
Sure, there's home field advantage and seeding to worry about. But let's not worry too hard.